If your cold bore goes where it's supposed to, there's no need for 2nd and 3rd shots.
Have you never tested a rifle/load combo as I've described?
Was that a serious answer and is this a serious question?
I'm sorry I try not to do this, but I gotta ask, how many big game animals have you killed? Not one person that I have ever met or hunted with that had killed much at all has not had to put more than one round in animals.