OK, assuming you plan to reload for either caliber and assuming both calibers are offered in the same pistol. Which would you pick and why?
I asked myself that question 4 decades ago, chose the .44 just I might need to buy factory ammo sometime - I've never regretted the choice.
But if I'd chosen .45 I'm sure I'd have never regretted it either. Win/win.
'Four legs good, two legs baaaad." ---------------------------------------------- "Jimmy, some of it's magic, Some of it's tragic, But I had a good life all the way." (Jimmy Buffett)