all this talk of 45colt/44 made me pull out a model 25-5 i have. original owner let it get some spots of rust on it, which i have been working on off and on. with that 270 grain rcbs bullet, especially in the hollowpoint configeration, i can't think of much i would run into that it couldn't handle. I still don't think hyper velocity is all of it. and i have handguns between 41 and 45 that will all push a 250grain something at 1000fps or over which i think in reality does it.