Brian Pearce's Redhawk only loads that approach 50,000psi, begin a half grain over Hodgdon's "Ruger only" data. Starting with 24.0gr under the 335gr CPBC, he gets 1366fps out of a 7½" Redhawk.
That's a half grain over max with a revolver three inches longer than my Bisley Vaquero.
My wrists would be swollen and begging for ice before I got through with a couple of cylinders of those top end loads.
I had some 300 grain LRN .458's on the shelf (100 bullets marked $7, guess they'd been up there for a while). I resized them to .452 and loaded with 23 grains of H110. They were healthy, only shot six of them - holding the rest in reserve...or something. For a heavy Colt load I like the 270SAA bullet in a Tier 2 loading, accurate and doesn't beat your wrists up - and I'm pretty sure it'll thump anything that needs it.
