I shoot both and love the 45 colt. [I would not give up my 44 mags] The 45 colt goes from mild to wild and seems right at home with either. I very seldom load down with 44's but not the case with my 45 colt. It is right at home with 255 cast at 850 fps. Than again for hunting, I go with max charges of 296 and either a 250 XTP or 325 gr LBT WFN depending on what I am hunting. Maybe it is just a mental thing with me. [loading down a 44 mag that is]