The 45 meanwhile has the edge in heavier bullet options and when velocity is not as important.
But it doesn't have an edge. As I posted earlier, I tested two identical guns (4 5/8" Rugers) with every heavy cast bullet tested by Hodgdon.
The .44: 310gr at 1314fps 320gr at 1282fps 330gr at 1226fps 355gr at 1130fps
The .45's: 300gr at 1176fps 325gr at 1241fps 335gr at 1225fps 360gr at 1060fps
Where is the .45's heavy bullet advantage? I'm not trying to be combative but this seems to be a popular myth that the .45Colt is somehow better with heavy bullets. I don't think this perception is based in reality.