[quote=Dirtfarmer]Non-handloader, I'd say .44 mag.
For Loonies, the .45 Colt offers a lot. It's my pick of the two and I have both.
I took a .44 three screw SBH, had Jim Stroh line bore to .45 Colt, fit a 6" Shilen barrel, build custom sights, fit a long ejector. I did a trigger stop, tweaked the trigger to near perfection.