The .280 Rem is a fine chambering and these comparisons don't mean much to myself.The eliminator for me is barrel length when using a rifle in the mountains.The .270.280,7×57 and the 7mm08 work well with a 22 " barrel . I choose my hunting rifle based on other factors, weight is a huge one for me (backpacking or horseback) - and your choice of the amazing bullets these days. We all handload here so factory ammunition availability is not an issue.