It's hard to beat a good 280 with good handloads for any nondangerous game. If you don't handload just get a 270.
But if you do,a 280 is mighty nice,and has a couple of advantages over the 270. One is that there are lots of premium bullets in weights of 160 grains and up. The 270 has one,the 160 grain Nosler semispitzer. Second is that there are lots of really high BC long range bullets for the 280,the 270 offers less options in this category as well.
The 270 is really the all around rifle for Everyman. The 280 is really the all around rifle for guy who want a 270 and 30-06 rolled into one and doen't mind handloading to get it.
Great post doc!
Regarding the 280AI, nobody should expect it to be a 7RM, but another 100fps is never a bad thing and really plays well with the heavier bullets the 280 can handle.
