Go for it, you won't be sorry. Keep it 8lbs or less, free-bore is fine, but please don't try to run 100gr bullets at 3800fps unless you have a 30" barrel.
Brass is easy yet spendy and reloading is straight forward. If you go with a 26" barrel, expect 85 grainers at around 3800, 100 grainers at around 3600, 110's at 35'ish, 115's at 34'ish, and 120's at 3300.
Most guys here recomend the 100gr TSX with a stiff load of RL-22 but don't overlook the bonded bullets either. I currently shoot the 110 Accubond at 3450fps (25" barrel)out of mine and I'm working with the 100gr Scirocco now. With it's higher B.C. and abilty to be pushed faster, it should be superior to most anything else.
I've taken 9 deer and 4 coyotes thus far with my 257 Bee and all were D.O.T.S. As I related to someone else earlier today, my 11 year old son says that my rifle does'nt just kill deer it burns them down.....classic!
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Not knocking the 257 Weatherby but the 25-06AI will get 3920 fps with the 87 grainers and with 10 grains less powder and brass is not hard to get when you can neck down 270 win and 30-06 too. Cheap brass
