Take recoil and versatility for different game out of the equation. Is either designed so that it can more easily be loaded for accuracy?
You can look at the recent thread asking what has been your experience with the 243 to see that it pretty consistently shoots well. and if I was going to shoot varmints as well as deer that is probably the way I'd go.
However my buddy's 7mm-08 shoots pretty well with little fuss too so to answer the question as you posed it above I would say No. You will probably see as much variation or finicky tendencies from rifle to rifle as you will between the two cartridges you mention unless you are talking a bench rail gun then you might see a minute difference and as to which of the two would win I have no idea, but in a sporter weight rifle No.
I was just reviewing this thread and missed it the first pass that you already have a 243 and 223. In that case IMHO it would be 7mm08 all the way.
