I have yet to meet a deer where my .243 and 85TSX/80TTSX can't penetrate vitals from any angle. I've seen a few whoppers take a dirt nap, and I'm not picky with my shot angles. The big boys don't give you an extra second to wait for the perfect presentation. Most of the time with the biggest bucks you take what you've given within 3-15 seconds, or you go home with a consolation deer. I've recovered 2 85gr X/TSX bullets. The second of the two entered the onside rear quarter, broke femur, penetrated paunch and vitals, and ended up in the opposite shoulder. The first bullet made the same trip in reverse.

Give me any chambering from .243 on up, but make SURE to give me a TSX/TTSX/NP/etc. to stoke it with.