Well, I've only taken about 70 or so Saskatchewan deer, but I would feel fully confident with a .243, or .250 Savage or .257 Roberts with good bullets. I usually have used something bigger because a lot of our hunting overlaps with moose, elk and bear seasons. I do not know one single local hunter who chooses a 300 magnum for whitetails, although a few do shoot 7mm Remington mags. Far more common are .270's, .308's, 30-06, 7mm-08, etc. etc.
A 25-06 is about ideal for open country whitetails in my opinion. Choosing a 300 magnum for any deer-only hunt seems kinda silly to me, besides being a little disrespectful to all that good venison. But if a visiting hunter wants to use a 300 mag and can shoot it well, they kill deer very effectively, that's for sure.

Last edited by castnblast; 09/23/13.