Center of chest shots, rear quartering shots, front quartering shots, they all work flawlessly for me using a .243 or .25-06 using any decent bullet from the Sierra GK to the Barnes TTSX. Although I'd rather have a Barnes up the snout if I know I might take any shot presented on a large buck. I don't pass just because the deer isn't perfectly perpendicular to me when it's time to shoot. BTDT several times.
I've seen too many X/TSX/TTSX bullets plow though 3' of game from .243 and .25-06 rifles, creating plenty or damage along the way, to support the notion that only the most ideal shots can be taken when using those cartridges.
