Bullet placement always trumps head stamp.
This is about as profound a statement as one can make.
If a fella can accurately shoot a 300 , 338, or even a 375 ( know two guys that hunt deer with them) get right at it!
I used to be able to but through the years and damage shoulders
Those big boomers are a no-go so lighter cartridges are the way for me, I simply shoot them better!
Cat