I never used the Fail Safes, although I have read reports that they tended to kill pretty slow, which isnt supprising.
I would also add that I killed an antelope with a 25 cal 100gr TSX at 250 yards or so and it died as if pole axes with a behind the shoulder shot. My brother used the same gun and load on another antelope the same trick with the same general shot placement at over 400 yards with the same result. However I had more than several deer run a ridiculous amount using the same gun and load.
JB was using the same bullet out of a 257 WTB IIRC and had an animal run way off as well.
The mechanisms of wounding are not unknown and it's also not unknown why monos work the way they do. They simply trade off damage via less shrapnel and less frontal area for penetration.