As JY Jones did in his book, One Man, One Rifle, One Land (I have if on my coffee table) he killed every species of North American big game with his Remington ADL in 30-06 with mostly 165 gr handloads, he did use 180s on occasion when merited for larger game. As I recall, he even had to have his rifle barrel trimmed back an inch or so when it wasn't shooting right. His scope was rudimentary by today's standard and I do think he replaced it once during his odyssey.
