For me the 30-06 is unnecessary powerful for deer and the like. I think it comes into its own with elk/moose sized stuff. But that's the nit-pickings of a rifle nut.

I've used the 30-06 on antelope, whitetail deer, mule deer, black bear and elk. Limited to one rifle/chambering for the world, my choice would be the 30-06.

I always find it amusing people don't think of the 30-06 as a "powerful" cartridge. In the post-Weatherby era, perhaps it isn't. But to me it's a very potent round, and perhaps the ideal, all-around, every-man's elk cartridge.

It works:

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“Perfection is Achieved Not When There Is Nothing More to Add, But When There Is Nothing Left to Take Away” Antoine de Saint-Exupery