I'd go with a 300 RUM stoked with 200 gr Accubonds topped with a reliable scope with turrets. I can only practice to 600 yards here so that would be my limit. For any shot over 200 yds the critter would need to be standing still (and only a slow walk under 200). A steady rest, a good rangefinder and little to no crossing wind would mean a bullet through the lungs almost every time.
