I have one, have had 2 others, and a 280 Rem. before that. For some reason, I always preferred one of the 280s over a 30-06. And the 280 AI can effectively replace a 7mm Rem. Mag (and certainly a 270, 280 Rem., or 30-06). I'm not bashing 30 cals, and I have a 300 Win. Mag. as well.
Going down from that, I use a .243. I have no need for 6.5 or 270 calibers.
I started out with Barnes 140 X, then XLC, then TTSX, then switched to the 145 LRX, and now also have the 139 LRX