I'm a big fan off the heavier bullets for the 257. People tout the 100's for their velocity potential, but the problem is, their BC's are horribly low. By the 300 yard mark, the 115's are going just as fast, but with substantially more energy and less wind drift. Beyond 300 the 115-120 gr bullets walk away from the 100's, especially the TTSX with it's barn door bc of .357.

I shoot the 115 Ballistic Tip in mine almost exclusively and occasionally the 110 Accubond. Both are spectacular killers. The 257 just flat hammers game.

As an aside, if you have any RL-25 lying around, give it a go. It's by far, given the best results with 115-120 gr bullets in every 257 Wby I've owned.