I've had a handful of 1911s - some good and some bad - and just picked up an Ed Brown a few weeks ago. I have a Wilson Combat that has been excellent as well. I appreciate the 1911 and what it has done and what it represents. I enjoy the heck out of mine.

That said...

There are so many other better options available now. There are quite a few makers (not just glock) making terrific pistols that will be more reliable and require less maintenance while holding twice as many rounds and weighing much less.

So, to answer your question, the 1911's weaknesses, IMO:

-mag capacity
-weight
-ammo sensitivity (many choke on hp stuff)
-maintenance requirements due to precision steel fitting

I'd venture to say that most of the old farts on this board are almost as old as the 1911, so they have a particular affinity towards them, but if i know I'm going to be in a situation that I'm going to need a handgun, my Wilson and Ed Brown will stay home. I'm reaching for a high cap polymer wonder.