there are so many variables, ammo, recoil tolerance/ability to shoot a lighter recoiling gun better, bullets used, part of body hit. One study I saw rated a 22 LR relatively close to a 9mm, and a 9mm was not that far from a 45ACP. All things considered if more people can make better hits with a 22LR then the data is going to show the 22LR as just about as lethal as a 9mm. That said I cannot believe a center mass hit with a 124 grain HST and a 230 grain HST will have remarkably different results.