I shot an armed home invasion intruder with a 12 gauge and Federal #4 buckshot. It is the same shotgun and load that I keep in the house today, along with a .40 S&W loaded with Federal Hydro-Shoks.
Did he live?
Yes, but without a functional right arm and a large portion of his liver and lower intestines.
He right hand and the stolen Glock that he was holding in it were damaged beyond repair.
As I said above, make a "bad shot" inside the house with buckshot, and you will blow his arm off.