The "Over or Under" shooting of a target at significant elevation difference should not be an issue if using a good compensating laser range finder......
My RF does the math for me and compensates for the angle, whether bow or rifle hunting. So, for me again... it's dial time for anything past my PBR.
If there isn't time to range a target before it gets away, there's little doubt that you really have time for much more than a WAG and a hold over or painting with a mil or moa reticle....imo of course.
My thoughts exactly and chances are if it’s that far it’d be a heckuva time to get a stable position and make sure the animal was where I could get to it and find it post shot.
