48 grs of H4895 and a 150 Interlock at 2800 fps will be very easy on the shoulder and blow a hole thru a white tail.
I shoot that same load with Sierra 150 PH's. Shoots down close to 1/2" in a Sauer 101. The other week I tested it in a Rem 7600 shooting with the original irons on it and with my eyes and a blurry rear sight it put 3 at 1.25" at 100, 4 shot group was 1.75". Just installed a peep on it, that should make it easier.