This is an sample of one.
I'm not a grizzly hunter, but hunt in grizzly country. I have taken 28 elk, 22 were bulls.
All with Nosler Partitions, Trophy Bonded, Swift A-Frame, Hornady Interbond, and Nosler Accubond. In roughly correct chronological order. You can see the theory I favored in selecting bullets from this list.
On Oct. 15 I used a 230 grain Berger OTM Hybrid to take a 6x5 bull. .300 Win Mag, range 350 yards, muzzle velocity 2775, impact velocity 2400 fps +or-. Bullet hit directly on the near side shoulder bone just above the "knee" and under the wide "blade", made a mess of the lungs near the heart, and I found this in the hide on the far side with no further bone hit. Retained weight 81 grains. The bull went down when hit, no tracking needed, the near shoulder was completely unhinged. Wish now I took more damage pics, wasn't trying to prove anything at that time.
My conclusion after what I witnessed I would trust this combo on a grizzly in most any scenario.

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