I guess a fella could use Bergers on charging grizzlies a couple of times, and if they didn't work, he could change to something else.
I'd bet that if they didn't work there wouldn't be a second time
We know they can work if placed well. The critical question, however, is whether they work better (or even as well) as other bullets when placed into a maliciously motivated animal in less than ideal locations for that is what one can expect under the circumstances (and which is why a lot of people like the long hole idea better.)
Sometimes, the air you 'let in'matters less than the air you 'let out'.