Never did it myself but a number of old mentors have pulled it off on interior grizzly and brown bear with a 270. Bullets (to be very specific)were 130 NPT,160 NPT,and 130 Bitterroot.
One among many reasons why I have to blink when someone says the cartridge is lacking somehow in the killing department.
I'm a bit more traditional and brought a 375 and 338 when I went up after them;but goes to show that even brown bears don't live long with jagged holes through heart and lungs.
