MH, Our brown bear season just closed four days ago and it marked the 34th year that I have been guiding in Alaska. If I have learned anything it is that while they can be amazingly tough and tenacious when wounded, they are still flesh and blood and all it takes to kill them is a well placed, stoutly constructed bullet. The last hunter in my camp who used a .270 with 150 Partitions dropped his bear virtually within it's tracks ( although it did spin before dropping) It certainly didn't go 24 feet. Does that mean the 270 a "better" round than your 375 ? Of course not, but it certainly means it is adequate for the hunter who is a competent shot.
Calibers like your 375, and my 458, may help compensate for more marginal hits or put the big bears down a little quicker and keep them down a second longer, but they are certainly no more lethal.
