For the original experiment to proceed without the possibility that RC raised, the initial population must have been from a single bacterium whose genome had been sequenced. Experiment would have been much harder, unnecessary and probably impossible with a random starting population. The mutations were documented by comparing the sequence of the DNA of the progenitor and progeny. Mismatches between the two sequences could only arise from mutations.


Last edited by carbon12; 11/18/09. Reason: clarification