It's good to see well considered discussion of long range hunting.
My observation has been that those who are not experienced with long range shooting often think it a stunt... or irresponsible. Those who have been doing it know what their rifle can do, and also realize the limitations.
I think RC is right on. Once your ballistic solutions have been field tested and tweaked to be true, wind is revealed as the most difficult variable. Drops remain predictable because gravity doesn't change, but those down and updrafts can sure play hell with a bullets flight.