This might sound like a cliche, but I trust Chronys about as far as I can throw them--which is much less than 100 yards.
My first .280 was a custom rifle by David Gentry, which I used throughout the 1990s on big game throughout North America, including my biggest mule deer and one of my two biggest caribou, out of a dozen. Used several different bullets and powders, but eventually settled on enough H4831 to get just under 3000 fps with the 150 Partition.
Whether any of that makes any difference is debatable. Have found that caliber, cartridge, powder and velocity make far less difference than the bullet and where it lands.
Ain't none of them magic without those two factors. Yet most hunters keep quoting muzzle velocities, bullet weight, etc. as if there's some consistently detectable difference in "killing power."
A good point (And well taken) I have been guilty of chasing velocity in both handguns and rifles in the past. I do not own a Chrony anymore. Just don't need it to be successful.
