Sky. dead right. Too high in the neck and you nip a high spine on the vertebrae. Deer goes down like a rock, jumps up like a rabbit and usaully is never seen again. Too low and you clip the esophagus, resulting in a deer that usaully gets away and slowly dies of starvation and gangrene.I doubt if a 22 cal/60 gr bullet at 3000fps + would even penetarte to the spine unless it sheds a lot of velocity pretty quick. Especially when I have seen 130-140 gr BT's blow up at the same speeds without reaching vitals.