The most popular cartridges in Alaska are the .30-06, .300WM, and .338WM. The 7mm Magnum comes next. The .375H&H is usually favored by the coastlines, probably because of the larger bears, but overall is vastly outnumbered by the other calibers. For the interior of Alaska where shots can be longer, the .338WM is quite nice. For close work you can use a 250-grain, or maybe a 275-grain A-frame. For the average hunting distance from 50 yards to 300 or so you can use a 225-grain to perhaps 250-grain, and for small game such as pronghorn past 300 yards there is nothing wrong with a 180-grain loaded around 2,900 fps.

By the way, when it comes to penetration, a 250-grain .33-caliber bullet has great SD. Take a look:
http://www.chuckhawks.com/rifle_SD_list.htm

Last edited by Ray; 04/09/16.