One thing I will say you can't go wrong using the most power rifle you can shoot accurate and handle the recoil for Big Bulls, the extra insurance can sometimes make the difference with other than perfect shot. Elk is where heavy for cal bullets make the difference if you have to angle a bullet to get to the through the paunch to get to the chest cavity.
A Doe walks out of the woods today and says, that is the last time I'm going to do that for Two Bucks.
