Do you know the difference between 'genetic code' and 'genome'?
You are technically right regarding a hypothetical organism with a deviated genetic code not being able to reproduce but not for the reason you think. Has nothing to do with how mules are made.
Yes, the genome equals 23pr in a human. Code refers to A-T-C-G sequencing.
You are FOS about "mules" having nothing to do with this specious arguement you cooked up.
Variations resulting in evolutionary change occur more gradually than a horse giving birth to a mule. You wouldn't be able to detect any difference from one generation to the next, and if it were favorable, it would only be slightly favorable (e.g., a slightly longer neck), resulting in that line only slightly out competing those without that slight variation during times of survival stress.