I've shot several factory loads in mine with no issues. I recall Darcy mentioning one particular loading to avoid, but don't remember which one it was. I typically shoot game in the shoulder area, something the folks in Africa were adamant about. The mono bullets excel for that type of bullet placement, and for me they've produced some pretty dramatic drop in their tracks kills. If I were more of a chest cavity shooter I'd think the NP or similar bullets might show quicker effects. The high shoulder shot that imparts shock into or severes the spine is very reliable and provides zero tracking jobs. I like that!