I have hunted with a chambered round 99% of the time when on foot. When I am on horseback, I don't have a round chambered 100% of time. Heck, you may even find a loaded rifle (or ten) in my house. I was always taught to treat them as if they were always loaded. The way I handle them never changes. If I see your muzzle pointed my direction. I will damn sure let you know where it will be placed if it ever happens again.
