A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness.
Sabeena Ahmed 1, Mohammad Mahbubul Karim 1, Allen G Ross 1, Mohammad Sharif Hossain 1, John D Clemens 1, Mariya Kibtiya Sumiya 1, Ching Swe Phru 1, Mustafizur Rahman 1, Khalequ Zaman 1, Jyoti Somani 2, Rubina Yasmin 3, Mohammad Abul Hasnat 4, Ahmedul Kabir 5, Asma Binte Aziz 1, Wasif Ali Khan 6 Affiliations expand • PMID: 33278625
Conflict of interest statement The authors declare that there are no known competing financial interests or personal relationships that could have appeared to influence the work described in this paper.
Cumulative viral recovery estimates in…
• Antiviral Effects of Ivermectin in COVID-19- Clinically Plausible? Shukla DAK, Misra DS.Int J Infect Dis. 2021 Aug;109:91. doi: 10.1016/j.ijid.2021.06.048. Epub 2021 Jun 24.PMID: 34175482 Free PMC article. No abstract available.
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References
1. Alam M.T., Murshed R., Bhiuyan E., Saber S., Alam R., Robin R. A Case Series of 100 COVID-19 Positive Patients Treated with Combination of Ivermectin and Doxycycline. J Bangladesh Coll Physic Surg. 2020;38:10–15. doi: 10.3329/jbcps.v38i0.47512. - DOI 2. Caly L., Druce J.D., Catton M.G., Jans D.A., Wagstaff K.M. 2020. "The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res, from https://www.ncbi.nlm.nih.gov/pubmed/32251768 (Caly et al. 2020), Apr 3. - PMC - PubMed 3. Centers for Disease Control and Prevention . 2020. Interim Clinical Guidance for Management of Patients with Confirmed 2019 Novel Coronavirus (2019-nCoV) Infection, Updated March 7, 2020. 4. Chiu S.H., Lu A.Y. In: Ivermectin and Abamectin. Campbell W.C., editor. Springer-Verlag; New York, NY: 1989. Metabolism and tissue residues; pp. 131–143. 5. Johns Hopkins University of Medicine COVID-19 . 2020. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University.https://coronavirus.jhu.edu/map.html (accessed 17.11.2020)