Powders of interest in the .458 WM and .458 WM+: Anything good in a .223 Rem.

Hodgdon's CFE 223 really works, cleaning copper out of bore.
It would be highly desirable for any 550-gr to 600-gr bullets no doubt, being a slower powder than the other two below.

Alliant's Power Pro Varmint seems ideal for 500-grainers.

Alliant's Power Pro 1200-R may be best reserved for lighter bullets, being quite a bit faster than VARMINT.
But it is said to have excellent ThermoBallisticIndependence, what I call TBI, not meaning Tennessee Bureau of Investigation.

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Don't forget about the .45-98 Sharps Belted with Blackhorn 209 and cast bullets, even those with PC-paint and gas check,
or greased and plain base, whatever turns your riflecrank,
heck even BP and paper-patched works wonderfully well in the .458 WM and .458 WM+:

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Ron aka "Rip" for Riflecrank Internationale Permanente
NRA Life Benefactor and Beneficiary
.458 Winchester Magnum, Magnanimous in Victory
THE WALKING DEAD does so remind me of Democrap voters. Donkeypox.