OK, with the rarity of 3000-pound bison bulls, only 1.0 H&H unit of TBPI is required for the "Ultimate Buffalo Rifle."
That will take care of about any critter up to 2500 pounds on the hoof.

Sir Jerry is onto a good load with his 450-gr TSX at 2418 fps with 83 grains of AA-2460.
Ditto Sir Bob with his 450-gr TSX at 2413 fps load with 84 grains of H335.
Both of those are from 24" barrels, corrected to MV by adding 11 fps to 5-yard chrono velocity, IIRC.

Previous top 450-grainer load from my Ruger No. 1 .458 WM with 24" barrel:
450-gr TSX, Hornady .458 WM brass, F-215 primer, COL 3.565", 87*F
83.0 grains AA-2230
3 shots, 5-yard Caldwell G2 chrono fps: 2493, 2495, 2492
Average = 2493 fps, so for BC = 0.369:
MV = 2504 fps

First 2 shots went into one hole at 50 yards and I pulled the third shot by a half inch,
or that is when my forend screw started bending and loosening. Ho hum. Fixed that.

TBIP if 450-gr TSX MV is only 2500 fps:

0 yards = 1.877
50 yards = 1.790
100 yards = 1.705
200 yards = 1.543
300 yards = 1.390
400 yards = 1.247
500 yards = 1.125
600 yards = 1.003

Better not shoot any 3000-pound bison bulls past 400 yards.
That is about the limit of my marksmanship on caribou anyway, with a .340 WbyMag, which is a puny cartridge compared to the .458 WM+.

Ron aka "Rip" for Riflecrank Internationale Permanente
NRA Life Benefactor and Beneficiary
.458 Winchester Magnum, Magnanimous in Victory
THE WALKING DEAD does so remind me of Democrap voters. Donkeypox.