Sir Jerry, Yes, I was researching "Mad Cow Disease" circa 1995, before it was "a thing." Buy a Donkey for that funny. You are certainly well armed with a 450-gr TSX from a .458 WM+ at 2420 fps MV. I would fear no mad cow even if I limited myself to 2400 fps with a .458/ 400-grainer.
Ron aka "Rip" for Riflecrank Internationale Permanente NRA Life Benefactor and Beneficiary .458 Winchester Magnum, Magnanimous in Victory THE WALKING DEAD does so remind me of Democrap voters. Donkeypox.