I have both 25-06 and 243. I have killed plenty with both and continue to use both.

My take on it is a 25-06 with a load of 52.5 grains of IMR-4350 and a 100 grain Nosler BT will kill deader more reliably, with less shots at longer range than the 243.

Other than that a 243 kills pretty dead at anything shorter than the distances the 25-06 is capable of...


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