I use them in my larger calibers & never had questionable performance, even on moose.
Always have a supply on hand for the .243 & 25-06, as back ups.
They're my "go-to" for starting out with a new (to me) rifle. Most of the time I don't need to try anything else. I've shot deer with the .30-06, .308, .280, and .243 Federal Fusions. No complaints at all.
In fact, I'm trying to think of a deer that ran after being shot with them and I think it's only one, shot with the .308, facing me. and it didn't go far.
